ANYTIME. ANYWHERE. ANY FOOD.1*

The oral TPO-RA patients can take when and where they want, with any food they want, on a consistent schedule.1-3

resources

Start with one pill, once a day

Start with the lowest dose of Doptelet needed to achieve and maintain a platelet count of ≥50x109/L. Dose adjustments are based on platelet count response. Do not use Doptelet to normalize platelet counts.1†‡§

Recommended starting dose:

20 mg

ONE PILL, ONCE DAILY1†

Titrate with one dose strength1

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Titration Calculator

This titration calculator is intended for use by healthcare professionals only as a guide for titrating Doptelet. It is not a substitute for professional medical judgment, clinical evaluation, or individualized patient assessment. Users are strongly advised to consult the Full Prescribing Information before making any dosing decisions.

Important Reminder: After initiating therapy with Doptelet or Doptelet Sprinkle, assess platelet counts weekly until a stable platelet count of ≥50x109/L has been achieved, and then obtain platelet counts weekly for at least 4 weeks following discontinuation of treatment.

  • Doptelet and Doptelet Sprinkle are not used to make platelet counts normal
  • Do not exceed a daily dose of 40 mg for Doptelet (2 tablets) or a daily dose of 20 mg for Doptelet Sprinkle (content of 2 capsules)

Want more information on dosing and titration? Answer the following questions:

1

How old is your patient?

Aged ≥1 to <6 years
(Doptelet Sprinkle oral granules) Aged ≥6 years
(Doptelet tablets)
2

I’m looking for dosing recommendations for:

Starting patients on
Doptelet Sprinkle oral granules Titrating for a patient already taking
Doptelet Sprinkle oral granules
2

I’m looking for dosing recommendations for:

Starting patients on
Doptelet tablets Titrating for a patient already taking
Doptelet tablets
3

Is your patient taking moderate or strong dual inducers or moderate or strong dual inhibitors of CYP2C9 and CYP3A4?

Yes No
3

What is your patient’s platelet count?
Platelet count (x109/L)

Below goal:<50 after at least 2 weeks of treatment At goal:≥50 to ≤200 Above goal:>200 to ≤400 Above goal:>400
4

My patient is taking:

Moderate or strong dual inhibitors of CYP2C9 and CYP3A4 Moderate or strong dual inducers of CYP2C9 and CYP3A4
4

My patient is currently taking Doptelet at this dosage strength:

LEVEL 1
10 mg
1x per week
LEVEL 2
10 mg
2x per week
OR
20 mg
1x per week
LEVEL 3
10 mg
3x per week
LEVEL 4
10 mg
1x per day
LEVEL 5
20 mg
3x per week
AND
10 mg
on 4 remaining days
LEVEL 6
20 mg
1x per day
Result
Recommended starting dose:
20 mg 1x per day.

New Calculation

TPO-RA characteristics to considerII¶

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Product characteristics

Doptelet1*#Eltrombopag2**Romiplostim3††

Oral administration

++-

Bioavailability not impacted by food type

+-+
mg

Single dosage strength*

+--
dna

No dose restrictions based on population ancestry demographics

+-+
Dosing comparisons do not imply efficacy or safety.
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*Food is required when taking Doptelet.1 
†Start patients taking moderate or strong dual inhibitors of CYP2C9 and CYP3A4 with 20 mg 3 times a week; start patients taking moderate or strong dual inducers of CYP2C9 and CYP3A4 with 40 mg once daily. Please see full Prescribing Information for additional information on dose adjustments.1
‡After initiating therapy with Doptelet, assess platelet counts weekly until a stable platelet count of ≥50×109/L has been achieved, and then obtain platelet counts monthly thereafter. Obtain platelet counts weekly for at least 4 weeks following discontinuation of Doptelet.1
§After adjusting dosage, wait 2 weeks to assess the effects of this regimen and any subsequent dose adjustments.1
IIDosing comparisons do not imply comparable efficacy or safety.
Includes Promacta®, Alvaiz®, and generic bioequivalents.2,3
#Doptelet has demonstrated safety in patients of Asian descent without the need for special dosing; no dose adjustments necessary for different conditions and population demographics.1
**Eltrombopag must be taken at least 2 hours before or 4 hours after other medications, calcium-rich foods, or supplements containing polyvalent cations.2 
††Romiplostim requires office visits for treatment injections.3 

TPO-RA=thrombopoietin receptor agonist.

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EXPLORE PEDIATRIC DOSING

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  1. DOPTELET (avatrombopag) [prescribing information]. Morrisville, NC: AkaRx, Inc; 2025.
  2. Promacta (eltrombopag) [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2023.
  3. Nplate (romiplostim) [prescribing information]. Thousand Oaks, CA: Amgen; 2025.